4-(N,N-Dimethylamino)-3-methylphenylboronic acid

4-(N,N-Dimethylamino)-3-methylphenylboronic acid - Names and Identifiers

Name	[4-(Dimethylamino)-3-methylphenyl]boronic acid
Synonyms	4-Borono-N,N,2-trimethylaniline [4-(Dimethylamino)-3-methylphenyl]boronic acid 4-(N,N-Dimethylamino)-3-methylphenylboronic acid
CAS	919496-59-6
InChI	InChI=1S/C9H14BNO2/c1-7-6-8(10(12)13)4-5-9(7)11(2)3/h4-6,12-13H,1-3H3

4-(N,N-Dimethylamino)-3-methylphenylboronic acid - Physico-chemical Properties

Molecular Formula	C9H14BNO2
Molar Mass	179.02

4-(N,N-Dimethylamino)-3-methylphenylboronic acid - Introduction

[4-(Dimethylamino)-3-methylphenyl]boronic acid, also known as [4-(Dimethylamino)-3-methylphenyl]boronic acid, is an organoboron compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: White to light yellow crystal powder
-Molecular formula: C10H15BN2O2
-Molecular weight: 206.05g/mol
-melting point: about 128-130 ℃
-Solubility: Soluble in most organic solvents, such as alcohols, ethers and ketones, insoluble in water

Use:
- [4-(Dimethylamino)-3-methylphenyl]boronic acid is an organoboron reagent, which is widely used in organic synthesis.
-It can be used as a catalyst or ligand to play an important role in metal-catalyzed reactions.
-It can participate in organic synthesis reactions such as Suzuki coupling reaction, Heck reaction and imidation reaction.

Method:
[4-(Dimethylamino)-3-methylphenyl]boronic acid can be prepared by the following steps:
1.4-amino -3-toluene boronic acid and methyl iodide are reacted to obtain 4-(methylamino)-3-toluene boronic acid.
2. An amine methylation reaction is carried out at the position of the methylamino group, using dimethylaminocopper bromide or methyl iodide.
3. Purification by crystallization or column chromatography gives [4-(Dimethylamino)-3-methylphenyl]boronic acid.

Safety Information:
- [4-(Dimethylamino)-3-methylphenyl]boronic acid dust may be irritating to the eyes, skin and respiratory system. Direct contact should be avoided when using.
-Need to operate in a well-ventilated place to avoid inhaling dust.
-Store away from fire and oxidant to prevent fire or explosion.
-When using or handling the compound, strictly follow safety procedures and wear personal protective equipment, such as safety glasses and gloves. If you are in contact with skin or eyes, rinse immediately with water and seek medical help.

Note: To ensure the safe and proper use of chemicals, please read and follow the relevant product safety data sheet (MSDS) and operating procedures before use.

Last Update：2024-04-10 22:29:15